Salpietro C D, Bisignano G, Fulia F, Marino A, Barberi I
Istituto Farmaco-Biologico, Università di Messina, Italie.
Arch Pediatr. 1999 Mar;6(3):317-20. doi: 10.1016/S0929-693X(99)80273-5.
Infections of the conjunctiva are frequent in the neonatal period. While Neisseria gonorrhoea and chemical agents were considered as the main etiologies of ophtalmiae neonatorum in the past, Chlamydia trachomatis is today a major cause of neonatal conjunctivitis. Thus in a study of 180 uni-or bilateral neonatal conjunctivitis the authors found a prevalence of Chlamydia trachomatis infection of 41%. The importance of the etiological diagnosis of neonatal conjunctivitis is emphasized, in order to define a specific treatment. Etiological diagnosis of Chlamydia trachomatis infection is based upon immunofluorescence and molecular diagnosis techniques (PCR, LCR). Prevention of neonatal Chlamydia trachomatis conjunctivitis relies upon screening and treatment of Chlamydia trachomatis infections in pregnant women and their partners. Treatment requires oral macrolides, the topical treatment being ineffective.
结膜感染在新生儿期很常见。过去,淋病奈瑟菌和化学物质被认为是新生儿眼炎的主要病因,而如今沙眼衣原体是新生儿结膜炎的主要病因。因此,在一项对180例单侧或双侧新生儿结膜炎的研究中,作者发现沙眼衣原体感染的患病率为41%。强调了新生儿结膜炎病因诊断的重要性,以便确定具体的治疗方法。沙眼衣原体感染的病因诊断基于免疫荧光和分子诊断技术(聚合酶链反应、连接酶链反应)。预防新生儿沙眼衣原体结膜炎依赖于对孕妇及其伴侣的沙眼衣原体感染进行筛查和治疗。治疗需要口服大环内酯类药物,局部治疗无效。