Engarås B, Hafström L, Kewenter J, Nilsson O, Wedel H
Department of Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.
Eur J Surg. 1999 Feb;165(2):110-6. doi: 10.1080/110241599750007270.
To establish standard serum concentrations of carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 50 and CA 242 in cancer-free subjects in the age group during which cancers are likely to develop.
Prospective study.
University hospital, Sweden.
Blood samples obtained by venepuncture on four occasions during one year.
Consultation with the Regional Cancer Registry to exclude those who had previously had malignant disease diagnosed or developed cancer during and up to two years after the end of the clinical part of the study. Serum concentrations of CEA, CA 50, and CA 242.
The 90th centile was 5.6 ng/ml for CEA, 30.1 U/ml for CA 50, and 24.5 U/ml for CA 242. The mean (SD) serum concentrations were 2.6 ng/ml (2.2) for CEA, 13.2 U/ml (11.4) for CA 50, and 10.6 U/ml (9.6) for CA 242. Serum concentrations of CEA were significantly higher (p < 0.001) among smokers. The intraindividual fluctuations were 16%, 16%, and 14%, respectively.
Serum concentrations of CEA, CA 50, and CA 242 were higher in this study than previously reported, probably because the subjects were older than in other reports. The fluctuations were small. Serum concentrations of CEA were higher in smokers than in non-smokers.
确定在癌症易发生年龄段的无癌受试者中癌胚抗原（CEA）、糖类抗原（CA）50和CA 242的标准血清浓度。
前瞻性研究。
瑞典大学医院。
在一年中4次通过静脉穿刺采集血样。
与地区癌症登记处协商，排除那些先前已被诊断患有恶性疾病或在研究临床部分期间及结束后两年内患癌的人。CEA、CA 50和CA 242的血清浓度。
CEA的第90百分位数为5.6 ng/ml，CA 50为30.1 U/ml，CA 242为24.5 U/ml。CEA的平均（标准差）血清浓度为2.6 ng/ml（2.2），CA 50为13.2 U/ml（11.4），CA 242为10.6 U/ml（9.6）。吸烟者的CEA血清浓度显著更高（p < 0.001）。个体内波动分别为16%、16%和14%。
本研究中CEA、CA 50和CA 242的血清浓度高于先前报道，可能是因为受试者比其他报道中的年龄更大。波动较小。吸烟者的CEA血清浓度高于非吸烟者。
