Seelig M H, DeVault K R, Seelig S K, Klingler P J, Branton S A, Floch N R, Bammer T, Hinder R A
Department of Surgery, Mayo Clinic Jacksonville, FL 32224, USA.
J Clin Gastroenterol. 1999 Apr;28(3):202-7. doi: 10.1097/00004836-199904000-00004.
Achalasia is an uncommon motility disorder of the esophagus with an uncertain etiology. Considerable debate exists regarding the most effective treatment for long-term relief of symptoms. For decades, pneumatic dilatation has been the primary treatment option, and surgery was reserved for patients who required repeated dilations or for those who were not willing to undergo the risk of perforation associated with dilatation. Recently botulinum toxin injection of the lower esophageal sphincter has been shown to provide substantial short-term relief from dysphagia; however, its effect only lasts for a short period of time. Recently, minimally invasive surgical techniques have been developed to perform a Heller myotomy effectively with an antireflux procedure. This has become a primary treatment option for many patients. We present a review of the outcome of different therapeutic options of achalasia with a special focus on laparoscopic procedures.
贲门失弛缓症是一种病因不明的罕见食管动力障碍性疾病。关于长期缓解症状的最有效治疗方法存在相当大的争议。几十年来,气囊扩张一直是主要的治疗选择,手术则适用于需要反复扩张的患者或不愿承担与扩张相关的穿孔风险的患者。最近,已证明注射肉毒杆菌毒素至食管下括约肌可在短期内显著缓解吞咽困难;然而,其效果仅持续较短时间。最近,已开发出微创外科技术,可有效地进行贲门肌切开术并同时进行抗反流手术。这已成为许多患者的主要治疗选择。我们对贲门失弛缓症不同治疗选择的结果进行综述,特别关注腹腔镜手术。