Wang Y L, Toris C B, Zhan G, Yablonski M E
The Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5540, USA.
Exp Eye Res. 1999 Apr;68(4):439-45. doi: 10.1006/exer.1998.0623.
The purpose of this study was to investigate, in cats, the effects of topical epinephrine on aqueous humor dynamics as measured by the non-invasive method of fluorophotometry and by other methods. Measurements were carried out on 12 cats before and after one week of twice daily treatment with 2% epinephrine hydrochloride to one eye. Aqueous flow and outflow facility were determined using fluorophotometry. Uveoscleral outflow was calculated from these results and was evaluated with anterior chamber perfusion of FITC-dextran. Outflow facility also was measured by tonography. Epinephrine-treated eyes, compared with their baseline values, showed a 31% reduction in intraocular pressure (P<0.001), a 23% reduction in aqueous flow (P<0.05), a 60% increase in fluorophotometric outflow facility (P<0.05), and a 43% increase in tonographic outflow facility (P<0.05). Treated eyes, compared with contralateral control eyes, showed a 27% reduction in IOP (P<0.005), a 25% reduction in aqueous flow (P<0.005), a 38% increase in fluorophotometric outflow facility (P<0.05), and a 34% increase in tonographic outflow facility. When evaluated by both fluorophotometry and FITC-dextran tracer methods, epinephrine had no significant effect on uveoscleral outflow. It was concluded that, in cats treated with topical epinephrine twice daily for a week, a reduction in intraocular pressure is induced by an increase in outflow facility and decrease in aqueous flow.
本研究的目的是通过荧光光度法这一非侵入性方法及其他方法，研究猫局部应用肾上腺素对房水动力学的影响。对12只猫进行测量，在一只眼睛每日两次使用2%盐酸肾上腺素治疗一周前后各进行一次测量。使用荧光光度法测定房水生成率和房水流出易度。根据这些结果计算葡萄膜巩膜途径房水流出量，并用荧光素异硫氰酸盐葡聚糖前房灌注法进行评估。也通过眼压描记法测量房水流出易度。与基线值相比，用肾上腺素治疗的眼睛眼压降低31%（P < 0.001），房水生成率降低23%（P < 0.05），荧光光度法测量的房水流出易度增加60%（P < 0.05），眼压描记法测量的房水流出易度增加43%（P < 0.05）。与对侧对照眼相比，治疗眼眼压降低27%（P < 0.005），房水生成率降低25%（P < 0.005），荧光光度法测量的房水流出易度增加38%（P < 0.05），眼压描记法测量的房水流出易度增加34%。当通过荧光光度法和荧光素异硫氰酸盐葡聚糖示踪剂法评估时，肾上腺素对葡萄膜巩膜途径房水流出无显著影响。得出的结论是，在每日两次局部应用肾上腺素治疗一周的猫中，眼压降低是由房水流出易度增加和房水生成率降低所致。
