Boscaro M, Armanini D, Mantero F
Quad Sclavo Diagn. 1976 Mar;12(1):39-54.
Results of routine methods for measurements of plasma cortisol and his urinary metabolites have been comparated with those of cortisol secretion rate (CSR) measured by simple isotopic dilution; the latter appears for his specify and precision, to be the most suitable for an exact evaluation of cortisol production by the adrenals. In normal subjects CSR resulted slightly lower than those reported in the literature; in obese subjects CSR was slightly higher than in normals, also when it was related to the urinary creatinine. In the patients with Cushing's syndrome, CSR was considerably higher, with no overlap with the obese subjects. The CSR was also useful in showing values lower than normal, in hypopituitarism, and in confirming hormone abnormal findings in thyroid diseases.
血浆皮质醇及其尿代谢产物常规测量方法的结果已与通过简单同位素稀释法测量的皮质醇分泌率（CSR）的结果进行了比较；就其特异性和精密度而言，后者似乎最适合准确评估肾上腺皮质醇的产生。在正常受试者中，CSR结果略低于文献报道的值；在肥胖受试者中，CSR略高于正常受试者，即使与尿肌酐相关时也是如此。在库欣综合征患者中，CSR显著更高，与肥胖受试者无重叠。CSR在显示垂体功能减退时低于正常的值以及在确认甲状腺疾病中的激素异常发现方面也很有用。
