Mellstedt H, Osterborg A
Department of Experimental Oncology, Uppsala University, Sweden.
Pathol Biol (Paris). 1999 Feb;47(2):211-5.
The idiotypic surface bound immunoglobulin structures on the myeloma cells can be regarded as a tumor specific antigen. Naturally occurring humoral and cellular immunity against the idiotype has been demonstrated. Idiotype immunization in combination with GM-CSF induced a specific T cell response in all studied myeloma patients (n = 5). The T cell response could be characterized as a type I response (gamma-IFN production) which seemed preferentially to be MHC class I restricted. Patients with a low tumor burden might be those which most favourably respond to this kind of therapeutic intervention.
骨髓瘤细胞表面结合的独特型免疫球蛋白结构可被视为一种肿瘤特异性抗原。针对独特型的天然体液免疫和细胞免疫已得到证实。独特型免疫与粒细胞-巨噬细胞集落刺激因子联合应用，在所有研究的骨髓瘤患者（n = 5）中均诱导出特异性T细胞反应。该T细胞反应可被表征为I型反应（γ-干扰素产生），似乎优先受到MHC I类分子限制。肿瘤负荷低的患者可能是对这种治疗干预反应最有利的患者。
