Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.
作者信息
Virkamäki A, Ueki K, Kahn C R
机构信息
Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
出版信息
J Clin Invest. 1999 Apr;103(7):931-43. doi: 10.1172/JCI6609.
Abstract
摘要
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本文引用的文献
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Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.给大鼠输注葡萄糖胺会迅速损害胰岛素对磷酸肌醇3激酶的刺激作用，但不会改变骨骼肌中Akt/蛋白激酶B的激活状态。
Diabetes. 1999 Feb;48(2):310-20. doi: 10.2337/diabetes.48.2.310.
2
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.胰腺β细胞中胰岛素受体的组织特异性敲除会产生与2型糖尿病类似的胰岛素分泌缺陷。
Cell. 1999 Feb 5;96(3):329-39. doi: 10.1016/s0092-8674(00)80546-2.
3
Trp64Arg mutation of beta3-adrenoceptor gene deteriorates lipolysis induced by beta3-adrenoceptor agonist in human omental adipocytes.
Diabetes. 1999 Jan;48(1):117-20. doi: 10.2337/diabetes.48.1.117.
4
An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement.含SH2结构域的5' 肌醇磷酸酶抑制胰岛素诱导的GLUT4转位和生长因子诱导的肌动蛋白丝重排。
Mol Cell Biol. 1999 Feb;19(2):1081-91. doi: 10.1128/MCB.19.2.1081.
5
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.肌肉特异性胰岛素受体基因敲除小鼠表现出非胰岛素依赖型糖尿病代谢综合征的特征，但糖耐量未改变。
Mol Cell. 1998 Nov;2(5):559-69. doi: 10.1016/s1097-2765(00)80155-0.
6
Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene.噻唑烷二酮类药物与胰岛素抵抗：过氧化物酶体增殖物激活受体γ激活可刺激CAP基因的表达。
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14751-6. doi: 10.1073/pnas.95.25.14751.
7
The diversity and possible functions of the inositol polyphosphate 5-phosphatases.肌醇多磷酸5-磷酸酶的多样性及可能的功能
Biochim Biophys Acta. 1998 Dec 8;1436(1-2):185-99. doi: 10.1016/s0005-2760(98)00132-5.
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Biochim Biophys Acta. 1998 Dec 8;1436(1-2):151-64. doi: 10.1016/s0005-2760(98)00133-7.
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Endocrinology. 1998 Dec;139(12):4832-8. doi: 10.1210/endo.139.12.6337.
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