Nair R, Abdool-Carrim A, Chetty R, Robbs J
Metropolitan Vascular Service and Department of Pathology, University of Natal Medical School, Congella, South Africa.
J Vasc Surg. 1999 Apr;29(4):600-7. doi: 10.1016/s0741-5214(99)70304-6.
Arterial aneurysms have only recently been associated with the human immunodeficiency virus (HIV). The clinical and pathological features of 10 HIV-positive patients with arterial aneurysms were retrospectively evaluated. These aneurysms were unusual in that they affected young black patients, occurred in atypical sites, and tended toward multiplicity. Surgery was performed in eight patients. Acute and chronic inflammatory changes were revealed by means of histologic examination of the aneurysm walls, with occlusion of the vasa vasora by inflammatory infiltrate or edema being a prominent feature. Culture of the aneurysm wall or thrombus yielded positive results in two patients. The association between HIV and aneurysms may be coincidental, caused by direct viral action or by bacterial infection resulting from immunosuppression. Implications for therapy are discussed, and the need for further study is highlighted.
动脉动脉瘤直到最近才被发现与人类免疫缺陷病毒（HIV）有关。对10例患有动脉动脉瘤的HIV阳性患者的临床和病理特征进行了回顾性评估。这些动脉瘤不同寻常之处在于它们影响年轻黑人患者，发生在非典型部位，且往往为多发性。8例患者接受了手术。通过对动脉瘤壁进行组织学检查发现有急性和慢性炎症改变，炎症浸润或水肿导致滋养血管闭塞是一个突出特征。两名患者的动脉瘤壁或血栓培养结果呈阳性。HIV与动脉瘤之间的关联可能是巧合，由病毒直接作用或免疫抑制导致的细菌感染引起。文中讨论了对治疗的影响，并强调了进一步研究的必要性。
