Hadjikhani N, Liu A K, Dale A M, Cavanagh P, Tootell R B
Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Charlestown 02129, USA.
Nat Neurosci. 1998 Jul;1(3):235-41. doi: 10.1038/681.
Prior studies suggest the presence of a color-selective area in the inferior occipital-temporal region of human visual cortex. It has been proposed that this human area is homologous to macaque area V4, which is arguably color selective, but this has never been tested directly. To test this model, we compared the location of the human color-selective region to the retinotopic area boundaries in the same subjects, using functional magnetic resonance imaging (fMRI), cortical flattening and retinotopic mapping techniques. The human color-selective region did not match the location of area V4 (neither its dorsal nor ventral subdivisions), as extrapolated from macaque maps. Instead this region coincides with a new retinotopic area that we call 'V8', which includes a distinct representation of the fovea and both upper and lower visual fields. We also tested the response to stimuli that produce color afterimages and found that these stimuli, like real colors, caused preferential activation of V8 but not V4.
先前的研究表明，在人类视觉皮层的枕颞叶下部区域存在一个颜色选择性区域。有人提出，这个人类区域与猕猴的V4区同源，V4区可以说是具有颜色选择性的，但这从未得到过直接验证。为了验证这个模型，我们使用功能磁共振成像（fMRI）、皮层扁平化和视网膜拓扑映射技术，将同一受试者中人类颜色选择性区域的位置与视网膜拓扑区域边界进行了比较。人类颜色选择性区域与从猕猴图谱推断出的V4区位置（其背侧和腹侧分区均不匹配）。相反，该区域与一个新的视网膜拓扑区域重合，我们将其称为“V8”，它包括中央凹以及上、下视野的独特表征。我们还测试了对产生颜色后像的刺激的反应，发现这些刺激与真实颜色一样，会优先激活V8而不是V4。
