肾移植患者中环孢素A的遗传毒性潜力。
Genotoxic potential of cyclosporin A in patients with renal transplantation.
作者信息
Palanduz S, Sever M S, Oztürk S, Taşçioğlu C, Karan M A, Sönmez G, Cefle K, Güler K
机构信息
Istanbul Faculty of Medicine, Department of Internal Medicine, Branch of Medical Genetics, Turkey.
出版信息
Cell Biol Toxicol. 1999 Feb;15(1):13-7. doi: 10.1023/a:1007594421458.
We analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing renal transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at the end of 3 months. To our knowledge, this is the first study demonstrating in vivo induction of SCE by CsA in humans. We conclude that CsA has a genotoxic potential on human lymphocytes.
我们分析了环孢素A（CsA）诱导姐妹染色单体交换（SCE）的情况，以此作为遗传毒性潜力的一个指标。在30例接受肾移植的患者中，在引入CsA之前和3个月后检测了SCE诱导情况。我们发现3个月末SCE频率显著增加。据我们所知，这是第一项在人体中证明CsA在体内诱导SCE的研究。我们得出结论，CsA对人类淋巴细胞具有遗传毒性潜力。
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