Maeda K, Yasuda H, Taniguchi Y, Terada M, Kikkawa R
Third Department of Medicine, Shiga University of Medical Science, Japan.
J Peripher Nerv Syst. 1999;4(1):13-8.
To characterize the morphology of the endoneurial microvasculature of degenerating nerves under hyperglycemia, the morphology of endoneurial microvessels in transected sciatic nerves was examined in normal and streptozotocin-induced diabetic rats. Three months after transection, the fascicular area and median vascular luminal area at the proximal level of the distal stump were significantly larger in diabetic than in control animals, whereas the number of vessels per fascicle was the same in the two groups. Arterioles in various stages of development were found in the centrifascicular region in some transected nerves. Serial sections revealed that these vessels originated from transperineural arterioles. The frequency and magnitude of vascular wall thickening were both greater in diabetic rats. These results suggest that the endoneurial microvasculature responds abnormally to nerve injury under hyperglycemia.
为了表征高血糖状态下变性神经的神经内膜微血管形态，我们在正常大鼠和链脲佐菌素诱导的糖尿病大鼠中检查了横断坐骨神经的神经内膜微血管形态。横断三个月后，糖尿病大鼠远端残端近端水平的束状区域和中位血管腔面积显著大于对照动物，而两组每束血管数量相同。在一些横断神经的离心束状区域发现了处于不同发育阶段的小动脉。连续切片显示这些血管起源于经神经小动脉。糖尿病大鼠血管壁增厚的频率和程度均更高。这些结果表明，高血糖状态下神经内膜微血管对神经损伤反应异常。
