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GLC determination of paracetamol and d-propoxyphene.

作者信息

Serfontein W J, de Villiere L S, Villiers L S, Botha D

出版信息

S Afr J Med Sci. 1976;41(4):297-304.

PMID:1019754
Abstract

d-Propoxyphene and d-norpropoxyphene were determined in rat plasms, rat brain homogenates and human plasma by means of GLC utilizing extracts obtained by micro-phase extraction of the drugs. Paracetamol was determined in the same samples by GLC separation of the O-butyrate derivative using caffeine as internal standard. The problems associated with the GLC determination of d-propoxyphene and d-norpropoxyphene in biological material are discussed and attention is drawn to the particular advantages of the micro-phase extraction procedure for the quantitative determination of these drugs.

摘要

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