Albers P, Bender H, Yilmaz H, Schoeneich G, Biersack H J, Mueller S C
Department of Urology, Bonn University, Germany.
Urology. 1999 Apr;53(4):808-11. doi: 10.1016/s0090-4295(98)00576-7.
To evaluate the accuracy of fluorodeoxyglucose positron emission tomography (PET) compared with computed tomography (CT) staging in patients with Stage I and II testicular germ cell tumors (GCTs).
From January 1995 to July 1997, in 37 patients with clinical Stage (CS) I (n = 25) and CS II (n = 12) GCT (24 nonseminomas, 13 seminomas), PET and CT were compared in the initial staging. After PET, the patients with nonseminomatous GCT were staged surgically by retroperitoneal lymph node dissection and the patients with seminomatous GCT were followed up clinically.
Correct staging by PET was achieved in 34 of 37 patients compared with correct CT staging in 29 of 37 patients. Of 10 metastatic lesions, 7 and 4 were detected by PET and CT, respectively. PET did not show false-positive signals. PET was unable to detect vital cancer with a maximal diameter less than 0.5 cm or teratoma at any size.
PET was useful for detecting viable tumor in lesions that are visible on CT scan and, thus, it may omit false-positive CS II lesions. However, PET was not able to identify mature teratoma. In this study, PET did not improve the staging in patients with CS I tumor.
评估氟脱氧葡萄糖正电子发射断层扫描（PET）与计算机断层扫描（CT）对Ⅰ期和Ⅱ期睾丸生殖细胞肿瘤（GCT）患者进行分期的准确性。
1995年1月至1997年7月，对37例临床分期（CS）为Ⅰ期（n = 25）和CSⅡ期（n = 12）的GCT患者（24例非精原细胞瘤，13例精原细胞瘤）在初始分期时进行PET和CT比较。PET检查后，非精原细胞瘤性GCT患者通过腹膜后淋巴结清扫术进行手术分期，精原细胞瘤性GCT患者进行临床随访。
37例患者中，PET正确分期34例，而CT正确分期29例。10处转移灶中，PET和CT分别检测出7处和4处。PET未显示假阳性信号。PET无法检测到最大直径小于0.5 cm的存活癌或任何大小的畸胎瘤。
PET有助于检测CT扫描可见病灶中的存活肿瘤，因此可能避免假阳性的CSⅡ期病灶。然而，PET无法识别成熟畸胎瘤。在本研究中，PET并未改善CSⅠ期肿瘤患者的分期。
