Fluvoxamine-methadone interaction.
作者信息
Alderman C P, Frith P A
机构信息
Repatriation General Hospital, South Australia, Australia.
出版信息
Aust N Z J Psychiatry. 1999 Feb;33(1):99-101. doi: 10.1046/j.1440-1614.1999.00522.x.
OBJECTIVE
The aim of this paper is to report a case of symptomatic methadone toxicity associated with fluvoxamine treatment.
CLINICAL PICTURE
A 28-year-old woman was admitted to hospital with severe hypoxaemia and hypercapnia indicating hypoventilation. Medication prior to admission had been stable and included methadone 70 mg daily and diazepam 2 mg twice daily. Three weeks before admission she had commenced treatment with fluvoxamine.
TREATMENT
Methadone was decreased to 50 mg daily and diazepam was tapered to zero.
OUTCOME
The serum methadone concentration decreased and oxygenation improved considerably.
CONCLUSIONS
Clinicians should be aware of the potential for a significant drug interaction between fluvoxamine and methadone.
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