Andrews J M, Nathan H, Malbert C H, Verhagen M A, Gabb M, Hebbard G S, Kilpatrick D, MacDonald S, Rayner C K, Doran S, Omari T, O'Young E, Frisby C, Fraser R J, Schoeman M, Horowitz M, Dent J
Department of Medicine, Royal Adelaide Hospital, Adelaide, South Australia 5000.
Am J Physiol. 1999 Apr;276(4):G886-94. doi: 10.1152/ajpgi.1999.276.4.G886.
There is currently no ideal method for concurrently assessing intraluminal pressures and flows in humans with high temporal resolution. We have developed and assessed the performance of a novel fiber-optic laser-Doppler velocimeter, mounted in a multichannel manometric assembly. Velocimeter recordings were compared with concurrent fluoroscopy and manometry following 50 barium swallows in healthy subjects. During these swallows, the velocimeter sensor was situated in either the proximal (24 swallows) or the distal (26 swallows) esophagus. It signaled intraluminal flow following 46 of 50 swallows. A greater mean number of deflections were recorded in the distal compared with the proximal esophagus (4. 3 vs. 2.4, P = 0.001). The maximal flow velocity recorded did not differ between the proximal and distal esophagus (76.7 vs. 73.8 mm/s). No velocimeter signals commenced after fluoroscopic lumen occlusion. The velocimeter signals were closely temporally related to fluoroscopic barium flow. Upward catheter movement on swallowing sometimes appeared to cause a velocimeter signal. Manometrically "normal" swallows were no different from "abnormal" swallows in the number and velocity of deflections recorded by the velocimeter. This novel instrument measures intraluminal flow velocity and pressures concurrently, thus enabling direct study of pressure-flow relationships. Flow patterns differed between the proximal and distal esophagus.
目前尚无一种理想的方法能够以高时间分辨率同时评估人体管腔内压力和流量。我们研发并评估了一种新型光纤激光多普勒测速仪的性能，该测速仪安装在多通道测压组件中。在50例健康受试者进行吞钡检查后，将测速仪记录结果与同步荧光透视和测压结果进行比较。在这些吞咽过程中，测速仪传感器位于食管近端（24次吞咽）或远端（26次吞咽）。在50次吞咽中有46次记录到管腔内血流信号。与食管近端相比，食管远端记录到的平均偏转次数更多（4.3比2.4，P = 0.001）。食管近端和远端记录到的最大流速无差异（76.7比73.8毫米/秒）。荧光透视显示管腔闭塞后未出现测速仪信号。测速仪信号在时间上与荧光透视钡剂流动密切相关。吞咽时导管向上移动有时似乎会引发测速仪信号。测速仪记录的偏转次数和速度在测压显示“正常”的吞咽与“异常”的吞咽之间并无差异。这种新型仪器能够同时测量管腔内流速和压力，从而可以直接研究压力-流量关系。食管近端和远端的血流模式不同。
