Greco R, Benito J, González M, de Miguel E, Vázquez J
Departamento de Pediatría y Cirugía, Hospital Infantil Gregorio Marañón, Madrid.
Cir Pediatr. 1999 Jan;12(1):16-21.
Lung transplantation is the only valid treatment for the severe neonatal pulmonary hypoplasia. The objective of this work is to develop and to establish a model of lobar lung transplantation.
Twenty pigs were used. Neonates 2-3 weeks; adults 10-12 weeks. Donors weighed 15 to 20 kg and recipients 5 to 7. In Group A animals were used to assess surgical anatomy and to develop surgical technique and instrumentation's model. The remainder animals (Group B) underwent left lobar lung transplantation. Hemodynamic and oxygenation data were collected before and after six hours of right lung exclusion.
All animals tolerated right lung exclusion. There was a significant increase in mean pulmonary artery pressure and a sustained reduction in cardiac output. Oxygenation values were not affected during unilateral lung perfusion.
The neonatal pig has a good tolerance to reduced-size lung transplantation. Lobar lung transplantation could increase substantially the donor's lung pool.
肺移植是治疗严重新生儿肺发育不全的唯一有效方法。本研究的目的是开发并建立一种肺叶移植模型。
使用了20头猪。新生儿猪2至3周龄；成年猪10至12周龄。供体体重15至20千克，受体体重5至7千克。A组动物用于评估手术解剖结构并开发手术技术和器械模型。其余动物（B组）接受左肺叶移植。在右肺排除6小时前后收集血流动力学和氧合数据。
所有动物均耐受右肺排除。平均肺动脉压显著升高，心输出量持续降低。单侧肺灌注期间氧合值未受影响。
新生猪对减体积肺移植具有良好的耐受性。肺叶移植可大幅增加供肺库。
