胆汁酸生物合成的调控。
Regulation of bile acid biosynthesis.
作者信息
Vlahcevic Z R, Pandak W M, Stravitz R T
机构信息
Division of Gastroenterology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
出版信息
Gastroenterol Clin North Am. 1999 Mar;28(1):1-25, v. doi: 10.1016/s0889-8553(05)70041-8.
Abstract
This article provides a review of the pathways through which cholesterol is degraded to bile acids. Regulation of key enzymes in the bile acid biosynthestic pathways is discussed. The important role of these pathways in the maintenance of cholesterol homeostasis and the possible therapeutic implications for the treatment of hypercholesterolemia are emphasized.
摘要
本文综述了胆固醇降解为胆汁酸的途径。讨论了胆汁酸生物合成途径中关键酶的调控。强调了这些途径在维持胆固醇稳态中的重要作用以及对高胆固醇血症治疗的潜在治疗意义。
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