胆汁盐的肠肝循环在脂蛋白代谢中的作用。
Role of the enterohepatic circulation of bile salts in lipoprotein metabolism.
作者信息
Cooper A D
机构信息
Research Institute, Palo Alto Medical Foundation, California, USA.
出版信息
Gastroenterol Clin North Am. 1999 Mar;28(1):211-29, viii. doi: 10.1016/s0889-8553(05)70051-0.
Abstract
The enterohepatic circulation of bile salts and cholesterol plays a central role in maintaining whole body cholesterol homeostasis. Hepatic lipoprotein metabolism is reviewed and the role of disturbances in bile salt metabolism in the pathogenesis of dyslipidemias is discussed. Further, the manipulation of bile salt metabolism to treat dyslipidemia is reviewed.
摘要
胆盐和胆固醇的肠肝循环在维持全身胆固醇稳态中起着核心作用。本文综述了肝脏脂蛋白代谢，并讨论了胆盐代谢紊乱在血脂异常发病机制中的作用。此外，还综述了通过调控胆盐代谢来治疗血脂异常的方法。
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