Krause P R, Straus S E
Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Bethesda, Maryland, USA.
Infect Dis Clin North Am. 1999 Mar;13(1):61-81, vi. doi: 10.1016/s0891-5520(05)70043-x.
Herpesviruses present difficult challenges in vaccine development because of their ability to evade immune clearance. Data and recommendations regarding the live-attenuated varicella vaccine are discussed. Approaches to developing vaccines to prevent herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV)-associated illnesses also are considered.
疱疹病毒因其逃避免疫清除的能力，在疫苗研发中带来了艰巨挑战。本文讨论了关于减毒活水痘疫苗的数据和建议。同时也探讨了开发预防单纯疱疹病毒（HSV）、巨细胞病毒（CMV）和爱泼斯坦 - 巴尔病毒（EBV）相关疾病疫苗的方法。
