[Childhood diabetes mellitus].

Long-term check of 68 type 1 diabetes patients (1978-1998); 23 under age 19, mean age 13.4 +/- 4.1 (group A) and 45 above age 20, mean age 26.7 +/- 4.9 (group B) were analyzed. 1) Mean onset age were 5.5 +/- 3.9 years old in group A whereas 7.8 +/- 3.5 in B. 2) In all type 1 diabetes high prevalences of positive HLA-DQ region gene and ICA and/or GADA were found. About 11% of all these patients showed the clinical pattern of slowly progressive variants. 3) Treatment modalities in individuals were successfully selected out of various combinations of insulin and multiple daily injection (MDI) styles. 4) Late complication prevalences were none in A and very little in B (8.9% background and none proliferative retinopathy, 2.2% nephropathy and 2.2% hypertension). 5) Five married females were able to have 7 normal babies. Sixteen type 2 diabetes patients, including one MODY 2, were successfully treated with combinations of sulfonylureas/alphaglucosidase inhibitors/insulin.