一种主要组织相容性复合体（MHC）编码的类泛素蛋白（FAT10）与纺锤体组装检查点蛋白MAD2非共价结合。
A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2.
作者信息
Liu Y C, Pan J, Zhang C, Fan W, Collinge M, Bender J R, Weissman S M
机构信息
Department of Genetics, Internal Medicine, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.
出版信息
Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4313-8. doi: 10.1073/pnas.96.8.4313.
Recently a number of nonclass I genes were discovered in the human MHC class I region. One of these, FAT10, encodes a protein consisting of two domains with homology to ubiquitin. FAT10 mRNA is expressed constitutively in some lymphoblastoid lines and dendritic cells and in certain other cells after gamma-interferon induction. FAT10 protein expression is controlled at several levels including transcription, translation, and protein stability. Yeast two-hybrid screening of a human lymphocyte library and immunoprecipitation studies revealed that FAT10 noncovalently associated with MAD2, a protein implicated in a cell-cycle checkpoint for spindle assembly during anaphase. Thus, FAT10 may modulate cell growth during B cell or dendritic cell development and activation.
最近，在人类主要组织相容性复合体（MHC）I类区域发现了一些非I类基因。其中之一，FAT10，编码一种由两个与泛素具有同源性的结构域组成的蛋白质。FAT10信使核糖核酸（mRNA）在一些淋巴母细胞系和树突状细胞中组成性表达，并在γ干扰素诱导后在某些其他细胞中表达。FAT10蛋白表达在转录、翻译和蛋白质稳定性等多个水平受到调控。对人类淋巴细胞文库进行酵母双杂交筛选和免疫沉淀研究表明，FAT10与MAD2非共价结合，MAD2是一种与后期纺锤体组装的细胞周期检查点有关的蛋白质。因此，FAT10可能在B细胞或树突状细胞发育和激活过程中调节细胞生长。
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