儿童淋巴瘤和神经母细胞瘤的皮肤试验

Skin tests in childhood lymphoma and neuroblastoma.

作者信息

Gasparini M, Bardare M, Fossati Bellani F

出版信息

Tumori. 1976 Jul-Aug;62(4):429-34. doi: 10.1177/030089167606200409.

DOI:10.1177/030089167606200409

PMID:1020049

Abstract

Intradermal skin test antigen (Varidase, Mumps, Candidine) and contact sensitization with 2,4-dinitrochlorobenzene (DNCB) were employed in 35 previously untreated children with neuroblastoma and malignant lymphoma, to evaluate delayed cutaneous hypersensitivity. Cutaneous responses were correlated to stage of disease and survival. The limited number of patients prevents any definitive conclusion. It is apparent, however, that in childhood non-Hodgkin's lymphoma anergy to DNCB is correlated to advanced stages with rapid progressive disease. In neuroblastoma and Hodgkin's disease patients skin test sensitization seems to be of questionable clinical value.

摘要

对35名未经治疗的神经母细胞瘤和恶性淋巴瘤患儿进行了皮内皮肤试验抗原（胰蛋白酶、腮腺炎、念珠菌素）以及用2,4 - 二硝基氯苯（DNCB）进行接触致敏试验，以评估迟发性皮肤超敏反应。皮肤反应与疾病分期及生存率相关。患者数量有限，无法得出任何确定性结论。然而，很明显，在儿童非霍奇金淋巴瘤中，对DNCB无反应与疾病晚期及快速进展性疾病相关。在神经母细胞瘤和霍奇金病患者中，皮肤试验致敏的临床价值似乎存疑。