Struthers N W
Urol Res. 1976;4(4):151-5. doi: 10.1007/BF00262347.
An in vivo study of the response of the dog ureter to local anaesthetics administered systemically and by ureteric perfusion, revealed that lidocaine, procaine, and mepivacaine, caused hyperperistalsis. The intravenous use of a near toxic dose produced hyperperistalsis of limited duration, whereas, intraureteric administration produced a prolonged and constant response with low dosage. The mode of action of these drugs is unclear as they are generally regarded as being non specific smooth muscle depressants. Continued peristalsis after prolonged exposure to local anaesthetic favours a myogenic rather than neurogenic conduction of the ureteric contraction wave.
一项关于犬输尿管对全身给药及输尿管灌注局部麻醉药反应的体内研究表明，利多卡因、普鲁卡因和甲哌卡因会引起输尿管蠕动亢进。静脉注射接近中毒剂量时会产生持续时间有限的蠕动亢进，而输尿管内给药则在低剂量时产生持久且恒定的反应。这些药物的作用方式尚不清楚，因为它们通常被认为是非特异性平滑肌抑制剂。长时间暴露于局部麻醉药后仍持续蠕动，这支持输尿管收缩波的肌源性传导而非神经源性传导。
