Davidorf F H, Makley T A, Lang J R
Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1976 Sep-Oct;81(5):849-61.
Twenty-two patients with choroidal melanomas were treated conservatively using radioactive radon rings with a mean follow-up of 43 months. In 14 patients there was successful tumor regression. Eight eyes were enucleated because of inadequate tumor response. Of the patients whose tumors were apparently destroyed, two have subsequently died of metastases and one eye was enucleated due to scleral rupture. Of the eight cases unsuccessfully treated, one has subsequently died of metastases. Radiation therapy is likely to be effective in patients with tumors 7 mm in diameter and 2 mm in elevation or less. Tumors larger than 12 mm in diameter and 3 mm in elevation do not respond adequately to irradiation. Relatively large doses of radiation (at least 8,000 rads to the tumor apex) must be used if the tumor is to be effectively obliterated. We believe that radiation effectively can destroy small choroidal melanomas.
22例脉络膜黑色素瘤患者采用放射性氡环进行保守治疗，平均随访43个月。14例患者肿瘤成功消退。8只眼因肿瘤反应不佳而被摘除眼球。在肿瘤明显被破坏的患者中，2例随后死于转移，1只眼因巩膜破裂而被摘除眼球。在8例治疗失败的病例中，1例随后死于转移。放射治疗可能对直径7毫米、隆起2毫米或更小的肿瘤患者有效。直径大于12毫米、隆起3毫米的肿瘤对放疗反应不佳。如果要有效消除肿瘤，必须使用相对大剂量的辐射（肿瘤顶点至少8000拉德）。我们认为放射能有效破坏小的脉络膜黑色素瘤。
