Hopf N J, Grunert P, Fries G, Resch K D, Perneczky A
Department of Neurosurgery, University of Mainz, Germany.
Neurosurgery. 1999 Apr;44(4):795-804; discussion 804-6. doi: 10.1097/00006123-199904000-00062.
Endoscopic third ventriculostomy (ETV) has been shown to be a sufficient alternative in the surgical treatment of occlusive hydrocephalus. To elucidate the ongoing discussion of timing, indication, and surgical technique, a retrospective analysis of 100 consecutive ETVs was conducted.
One hundred ETVs were performed in 95 patients (43 female and 52 male patients). Their age ranged from 3 weeks to 77 years (mean age, 36 yr). Hydrocephalus was caused by aqueductal stenosis in 40 patients, space-occupying lesions in 42, and intraventricular or subarachnoid hemorrhage in 8. One patient had postinflammatory hydrocephalus, and four patients had occlusive hydrocephalus of unknown origin. In 33 cases, surgery was performed using stereotactic guidance.
ETV was accomplished in 98 of 100 cases. The overall success rate was 76%. Patients with benign space-occupying lesions and nontumorous aqueductal stenosis had the highest success rates, which were 95 and 83%, respectively. Complications were arterial bleeding in one case, venous bleeding in three cases, intracerebral bleeding in one case, and infection in one case. There were no permanent morbidities or mortalities.
ETV is most effective in treating uncomplicated occlusive hydrocephalus caused by aqueductal stenosis and space-occupying lesions. ETV is still effective in two-thirds of the patients with previous infections or intraventricular bleeding. Patients who have previously undergone shunting and who have occlusive hydrocephalus should undergo ETV at the time of shunt failure, with immediate ligation or removal of the shunt device. In selected cases of distorted anatomy or impaired visual conditions, stereotactic guidance is helpful.
内镜下第三脑室造瘘术(ETV)已被证明是治疗梗阻性脑积水的一种有效替代手术方法。为阐明关于手术时机、适应症和手术技术的持续讨论,我们对连续100例ETV手术进行了回顾性分析。
对95例患者(43例女性和52例男性)进行了100次ETV手术。患者年龄从3周至77岁不等(平均年龄36岁)。40例患者的脑积水由导水管狭窄引起,42例由占位性病变引起,8例由脑室内或蛛网膜下腔出血引起。1例患者患有炎症后脑积水,4例患者患有不明原因的梗阻性脑积水。33例手术采用立体定向引导。
100例中有98例完成了ETV手术。总体成功率为76%。良性占位性病变和非肿瘤性导水管狭窄患者的成功率最高,分别为95%和83%。并发症包括1例动脉出血、3例静脉出血、1例脑内出血和1例感染。无永久性致残或死亡病例。
ETV治疗由导水管狭窄和占位性病变引起的单纯性梗阻性脑积水最为有效。对于既往有感染或脑室内出血的患者,ETV在三分之二的病例中仍然有效。既往接受过分流手术且患有梗阻性脑积水的患者,应在分流失败时进行ETV手术,并立即结扎或移除分流装置。在解剖结构扭曲或视力受损的特定病例中,立体定向引导是有帮助的。