Suzuki T, Mabuchi K, Fukazawa N
Life Sciences Laboratory, Performance Materials R&D Center, Mitsui Chemicals, Inc., Mobara, Chiba, Japan.
Bioorg Med Chem Lett. 1999 Mar 8;9(5):659-62. doi: 10.1016/s0960-894x(99)00056-6.
We synthesized the glucuronides of MS-209 to identify the two main unknown metabolites in human urine. Reaction of MS-209 and glucuronyl trichloroacetimidate gave two beta-isomers, which were each glucuronate of (R)- and (S)-MS-209. These spectrum data were identical with the metabolites.
我们合成了MS-209的葡糖醛酸苷，以鉴定人尿液中的两种主要未知代谢物。MS-209与三氯乙酰亚胺葡糖醛酸反应生成了两种β-异构体，分别是(R)-和(S)-MS-209的葡糖醛酸酯。这些光谱数据与代谢物一致。
