抗肿瘤剂187：取代的8,8-二甲基-2H,8H-吡喃并[6,5-h]喹啉-2-酮及相关化合物的合成与细胞毒性
Antitumor agents 187: synthesis and cytotoxicity of substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds.
作者信息
Yang Z Y, Xia Y, Xia P, Tachibana Y, Bastow K F, Lee K H
机构信息
Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360, USA.
出版信息
Bioorg Med Chem Lett. 1999 Mar 8;9(5):713-6. doi: 10.1016/s0960-894x(99)00065-7.
Abstract
Several substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-ones and related compounds were synthesized and evaluated for their in vitro cytotoxicity against a panel of human tumor cell lines. The most active compound (3) showed significant cytotoxic activity with GI50 values in the micromolar range.
摘要
合成了几种取代的8,8-二甲基-2H,8H-吡喃并[6,5-h]喹啉-2-酮及相关化合物，并评估了它们对一组人肿瘤细胞系的体外细胞毒性。活性最强的化合物（3）表现出显著的细胞毒性活性，其GI50值在微摩尔范围内。
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