Hartgrink H H, Wille J, König P, Hermans J, Breslau P J
Leiden University Medical Center, Department of Surgery, K6 50, PO Box 9600, 2300 RC Leiden, The Netherlands.
Clin Nutr. 1998 Dec;17(6):287-92. doi: 10.1016/s0261-5614(98)80321-x.
Pressure sores are a frequent problem, especially in elderly patients. Nutritional status may influence the incidence, progression and severity of pressure sores, data, however, are contradictory (1). The purpose of this study was to determine the effect of supplemental feeding on the nutritional status and the development and severity of pressure sores. The effect of supplemental feeding overnight (tube +) on patients with a fracture of the hip and a high pressure-sore risk score, was studied in a randomized clinical trial. The control group (tube -) had no supplemental feeding. After informed consent, 140 patients were randomized, and 129 of these took part in the trial (62 tube +, and 67 tube -). Protein and energy intake, haemoglobin, serum albumin, total serum protein and pressure-sore grade were measured at admission and after 1 and 2 weeks. Of the 62 patients randomized for tube feeding (tube +), only 25 tolerated their tube for more than 1 week and 16 for 2 weeks. Nevertheless, energy and protein intake was significantly higher in the tube + group (P < 0.001). This, however, did not significantly influence total serum protein, serum albumin and development and severity of pressure sores after 1 and 2 weeks. Comparison of the actually tube fed group (n=25 at 1 week, n = 16 at 2 weeks) and the control group showed a 2-3 times higher protein and energy intake (P < 0.0001), and a significantly higher total serum protein and serum albumin after 1 and 2 weeks in the actually tube fed group (all P < 0.001). Pressure-sore development and severity were not significantly influenced in the actually tube fed group. We conclude that we were not able to show a significant decrease in development and severity of pressure sores, because the nasogastric tube for supplemental feeding was not well tolerated in this patient group. Nevertheless, tube feeding overnight does result in a significant higher protein and energy intake, and has a significant effect on nutritional status in the actually tube-fed group. Other means of supplemental feeding will have to be used in order to answer the question of whether supplemental feeding can decrease development and severity of pressure sores.
压疮是一个常见问题,尤其在老年患者中。营养状况可能会影响压疮的发生率、进展及严重程度,然而相关数据却相互矛盾(1)。本研究旨在确定补充喂养对营养状况以及压疮发生和严重程度的影响。在一项随机临床试验中,研究了夜间补充喂养(鼻饲+)对髋部骨折且压疮风险评分高的患者的影响。对照组(鼻饲-)不进行补充喂养。在获得知情同意后,140名患者被随机分组,其中129名参与了试验(62名鼻饲+,67名鼻饲-)。在入院时以及1周和2周后测量蛋白质和能量摄入量、血红蛋白、血清白蛋白、总血清蛋白以及压疮等级。在随机分配接受鼻饲喂养(鼻饲+)的62名患者中,只有25名耐受鼻饲超过1周,16名耐受2周。然而,鼻饲+组的能量和蛋白质摄入量显著更高(P<0.001)。不过,这在1周和2周后并未显著影响总血清蛋白、血清白蛋白以及压疮的发生和严重程度。对实际接受鼻饲的组(1周时n = 25,2周时n = 16)和对照组进行比较,结果显示实际接受鼻饲的组蛋白质和能量摄入量高2至3倍(P<0.0001),且在1周和2周后总血清蛋白和血清白蛋白显著更高(所有P<0.001)。实际接受鼻饲的组中压疮的发生和严重程度未受到显著影响。我们得出结论,由于该患者群体对用于补充喂养的鼻胃管耐受性不佳,我们未能证明压疮的发生和严重程度有显著降低。尽管如此,夜间鼻饲确实会使蛋白质和能量摄入量显著更高,并且对实际接受鼻饲的组的营养状况有显著影响。为了回答补充喂养是否能降低压疮的发生和严重程度这一问题,将不得不采用其他补充喂养方式。