Liu Ming, Yang Jing, Yu Xi, Huang Xiao, Vaidya Sushan, Huang Fuguo, Xiang Zhou
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People's Republic of China.
Department of Pain, Xiamen No 2 Hospital, Xiamen, Fujian Province, People's Republic of China.
Clin Interv Aging. 2015 May 11;10:849-58. doi: 10.2147/CIA.S74951. eCollection 2015.
The effect of perioperative oral nutritional supplementation (ONS) on elderly patients after hip surgery remains controversial. This study intended to ascertain whether perioperative ONS is beneficial for the rehabilitation of elderly patients after hip surgery.
We searched databases including PubMed, Embase, and the Cochrane Central Register of Controlled Trials for articles published up to May 2014. Randomized controlled trials of ONS for elderly patients after hip surgery were included.
The combined trials showed that ONS had a positive effect on the serum total protein (P<0.00001) and led to a significantly decreased number of complications (P=0.0005). Furthermore, data from the infection subgroups showed significant decreases in wound infection (P=0.02), respiratory infection (P=0.04), and urinary tract infection (P=0.03). Clinical observation suggests that the intervention may improve the level of serum albumin, although the data did not reach statistical significance (P=0.48). Regarding mortality, there was no significant statistical difference between the intervention group and the control (P=0.93).
Based on the evidence available, this meta-analysis is consistent with the hypothesis that perioperative ONS can help elderly patients recover after hip surgery and reduce complications.
围手术期口服营养补充(ONS)对老年髋部手术后患者的影响仍存在争议。本研究旨在确定围手术期ONS是否有利于老年髋部手术后患者的康复。
我们检索了包括PubMed、Embase和Cochrane对照试验中心注册库在内的数据库,以获取截至2014年5月发表的文章。纳入了关于老年髋部手术后患者ONS的随机对照试验。
综合试验表明,ONS对血清总蛋白有积极影响(P<0.00001),并导致并发症数量显著减少(P=0.0005)。此外,感染亚组的数据显示伤口感染(P=0.02)、呼吸道感染(P=0.04)和尿路感染(P=0.03)显著减少。临床观察表明,该干预可能会提高血清白蛋白水平,尽管数据未达到统计学显著性(P=0.48)。关于死亡率,干预组与对照组之间无显著统计学差异(P=0.93)。
基于现有证据,本荟萃分析与以下假设一致,即围手术期ONS可帮助老年髋部手术后患者康复并减少并发症。