Fletcher J R, McKee A, Anderson R, Watson L
Trans Am Soc Artif Intern Organs. 1978;24:315-9.
Four hr veno-arterial cardiopulmonary bypass via a median sternotomy utilizing a membrane oxygenator was done in 15 baboons. A comparison of perfusion with and without anticoagulants was made. From this study systemic heparin had no advantage over no anticoagulants. These findings, in a clinically-relevant primate model, suggest that the scientific basis for the use of systemic heparin in membrane oxygenation is unclear.
对15只狒狒实施了经正中胸骨切开术、使用膜式氧合器进行4小时的静脉-动脉体外循环。对比了使用抗凝剂和不使用抗凝剂的灌注情况。该研究表明，全身使用肝素相较于不使用抗凝剂并无优势。在这个具有临床相关性的灵长类动物模型中的这些发现提示，在膜式氧合中使用全身肝素的科学依据尚不清楚。
