• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch.

作者信息

Reddy G V, Rodrigues V

机构信息

Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400005, India.

出版信息

Development. 1999 May;126(10):2083-92. doi: 10.1242/dev.126.10.2083.

DOI:10.1242/dev.126.10.2083
PMID:10207134
Abstract

Specification of cell fate in the adult sensory organs is known to be dependent on intrinsic and extrinsic signals. We show that the homeodomain transcription factor Prospero (Pros) acts as an intrinsic signal for the specification of cell fates within the mechanosensory lineage. The sensory organ precursors divide to give rise to two secondary progenitors - PIIa and PIIb. Pros is expressed in PIIb, which gives rise to the neuron and thecogen cells. Loss of Pros function affects the identity of PIIb and neurons fail to differentiate. Pros misexpression is sufficient for the transformation of PIIa to PIIb fate. The expression of Pros in the normal PIIb cell appears to be regulated by Notch signaling.

摘要

相似文献

1
Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch.
Development. 1999 May;126(10):2083-92. doi: 10.1242/dev.126.10.2083.
2
A glial cell arises from an additional division within the mechanosensory lineage during development of the microchaete on the Drosophila notum.在果蝇背板上微刚毛的发育过程中，神经胶质细胞起源于机械感觉谱系内的一次额外分裂。
Development. 1999 Oct;126(20):4617-22. doi: 10.1242/dev.126.20.4617.
3
Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs.麻木蛋白和α-衔接蛋白调节桑波多内吞作用，以确定果蝇外周感觉器官中的细胞命运。
EMBO Rep. 2005 Sep;6(9):836-42. doi: 10.1038/sj.embor.7400500.
4
Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless.在果蝇感觉器官谱系中，由Numb/Notch信号介导的二元细胞命运决定中，只有一部分需要无毛抑制因子。
Development. 1997 Nov;124(22):4435-46. doi: 10.1242/dev.124.22.4435.
5
Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division.仅在果蝇心脏的不对称谱系中，无论有无细胞分裂，Notch都会拮抗生肌细胞的命运。
Development. 2003 Jul;130(13):3039-51. doi: 10.1242/dev.00484.
6
Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage.普洛斯彼罗在果蝇成虫外周感觉器官谱系中，无需不对称定位就能区分姐妹细胞的命运。
Development. 1999 May;126(10):2063-71. doi: 10.1242/dev.126.10.2063.
7
Unequal segregation of Neuralized biases Notch activation during asymmetric cell division.在不对称细胞分裂过程中，神经化因子的不均等分离使Notch激活产生偏差。
Dev Cell. 2003 Jul;5(1):139-48. doi: 10.1016/s1534-5807(03)00187-4.
8
Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling.普洛斯特和帕克斯 2 组合调控 Ras 和 Notch 依赖的信号转导来控制神经细胞命运决定。
Neural Dev. 2011 May 3;6:20. doi: 10.1186/1749-8104-6-20.
9
Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division of sensory organ precursor cells.Par3 与 Sanpodo 合作，在感觉器官前体细胞不对称分裂后组装 Notch 簇。
Elife. 2021 Oct 1;10:e66659. doi: 10.7554/eLife.66659.
10
Binary cell death decision regulated by unequal partitioning of Numb at mitosis.有丝分裂时由Numb不均等分配调控的二元细胞死亡决定
Development. 2002 Oct;129(20):4677-84. doi: 10.1242/dev.129.20.4677.

引用本文的文献

1
Multifunctional glial support by Semper cells in the Drosophila retina.果蝇视网膜中Semper细胞的多功能神经胶质支持作用。
PLoS Genet. 2017 May 31;13(5):e1006782. doi: 10.1371/journal.pgen.1006782. eCollection 2017 May.
2
Linking cell surface receptors to microtubules: tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis.将细胞表面受体与微管相连：微管蛋白折叠辅助因子D在神经元形态发生过程中介导唐氏综合征细胞黏附分子（Dscam）的功能。
J Neurosci. 2015 Feb 4;35(5):1979-90. doi: 10.1523/JNEUROSCI.0973-14.2015.
3
The Drosophila Sp8 transcription factor Buttonhead prevents premature differentiation of intermediate neural progenitors.
果蝇Sp8转录因子“钮头”可防止中间神经祖细胞过早分化。
Elife. 2014 Oct 6;3:e03596. doi: 10.7554/eLife.03596.
4
Mef2 interacts with the Notch pathway during adult muscle development in Drosophila melanogaster.在黑腹果蝇的成虫肌肉发育过程中，Mef2与Notch信号通路相互作用。
PLoS One. 2014 Sep 23;9(9):e108149. doi: 10.1371/journal.pone.0108149. eCollection 2014.
5
Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.PGAM5 通过调控果蝇蘑菇体中线粒体凋亡预防从而增强果蝇对热激的抗性。
PLoS One. 2012;7(2):e30265. doi: 10.1371/journal.pone.0030265. Epub 2012 Feb 7.
6
A new Prospero and microRNA-279 pathway restricts CO2 receptor neuron formation.一个新的普罗透斯和 microRNA-279 通路限制了 CO2 受体神经元的形成。
J Neurosci. 2011 Nov 2;31(44):15660-73. doi: 10.1523/JNEUROSCI.2592-11.2011.
7
A transient expression of Prospero promotes cell cycle exit of Drosophila postembryonic neurons through the regulation of Dacapo.Prospero 的瞬时表达通过调节 Dacapo 促进果蝇胚胎后神经元退出细胞周期。
PLoS One. 2011 Apr 28;6(4):e19342. doi: 10.1371/journal.pone.0019342.
8
Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling.普洛斯特和帕克斯 2 组合调控 Ras 和 Notch 依赖的信号转导来控制神经细胞命运决定。
Neural Dev. 2011 May 3;6:20. doi: 10.1186/1749-8104-6-20.
9
Notch regulates numb: integration of conditional and autonomous cell fate specification.Notch 调控 numb：条件和自主细胞命运特化的整合。
Development. 2011 Jan;138(2):215-25. doi: 10.1242/dev.050161. Epub 2010 Dec 9.
10
SCAR/WAVE is activated at mitosis and drives myosin-independent cytokinesis.SCAR/WAVE 在有丝分裂中被激活，并驱动肌球蛋白非依赖性胞质分裂。
J Cell Sci. 2010 Jul 1;123(Pt 13):2246-55. doi: 10.1242/jcs.063735. Epub 2010 Jun 8.