Hathaway P B, Mankoff D A, Maravilla K R, Austin-Seymour M M, Ellis G K, Gralow J R, Cortese A A, Hayes C E, Moe R E
Department of Radiology, University of Washington School of Medicine, Seattle 98195-7115, USA.
Radiology. 1999 Mar;210(3):807-14. doi: 10.1148/radiology.210.3.r99mr43807.
To assess the performance and potential clinical effects of combined 2-[fluorine 18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) and magnetic resonance (MR) imaging of the axilla and brachial plexus in patients suspected of having local-regional breast cancer metastases.
Upper-body FDG PET and axillary and supraclavicular MR imaging were performed in 10 patients (age range, 45-71 years) with clinical findings suggestive of breast cancer metastases. Medical records were reviewed retrospectively. Imaging findings were correlated with clinical data and follow-up findings in all patients. Surgical findings were available in four patients.
Nine patients had local-regional breast cancer metastases. MR imaging was diagnostic for tumor in five patients and was indeterminate in four patients with axillary or chest wall metastases. With FDG PET, metastatic tumor was positively identified in all nine patients. MR imaging was useful for determining the relationship of metastatic tumor to axillary and supraclavicular neurovascular structures. FDG PET helped confirm metastases in patients with indeterminate MR imaging findings and depicted unsuspected metastases outside the axilla.
MR imaging and FDG PET are complementary in detecting and characterizing local-regional breast cancer metastases. Combined FDG PET and MR imaging provide useful treatment-planning data for patients clinically suspected of having recurrent axillary or supraclavicular breast cancer.
评估联合使用2-[氟-18]氟-2-脱氧-D-葡萄糖（FDG）正电子发射断层扫描（PET）和磁共振（MR）成像检查腋窝及臂丛神经，对疑似局部区域性乳腺癌转移患者的诊断效能及潜在临床效果。
对10例（年龄范围45 - 71岁）临床检查提示有乳腺癌转移的患者进行上身FDG PET及腋窝和锁骨上区MR成像检查。对病历进行回顾性分析。将所有患者的影像检查结果与临床资料及随访结果进行对照。4例患者有手术所见。
9例患者存在局部区域性乳腺癌转移。MR成像诊断出5例患者的肿瘤，4例腋窝或胸壁转移患者的结果不确定。FDG PET在所有9例患者中均明确发现了转移瘤。MR成像有助于确定转移瘤与腋窝及锁骨上神经血管结构的关系。FDG PET有助于确诊MR成像结果不确定患者的转移情况，并显示出腋窝外意外的转移灶。
MR成像和FDG PET在检测及鉴别局部区域性乳腺癌转移方面具有互补性。联合FDG PET和MR成像可为临床疑似复发性腋窝或锁骨上乳腺癌的患者提供有用的治疗计划数据。
