The effect of testosterone, progesterone and orchidectomy on the kidney of common ground squirrel, Funambulus pennanti.

Histological changes, caused by testosterone, progesterone and castration in the kidney of common ground squirrel, Funambulus pennanti have been described in this report. It is concluded that kidney is no doubt an endocrine receptor but behaves specifically to androgens as well as estrogens giving dis-similar results. The extent of toxicity has been measured with the help of histoenzymological reactions previously made. Prolonged administration of androgens and estrogens to patients in clinical practice is warned. It is a must firstly to determine the dose which is well tolerated by healthy subjects. These safe levels should not be exceeded under any circumstances.