Lohiya N K
Acta Eur Fertil. 1976 Sep;7(3):257-65.
A single subcutaneous injection of cadmium chloride caused reversible destruction in the testis of palm, squirrel, Funambulus pennanti. Marked regression in testicular weight and seminiferous tubule diameter associated with complete necrosis of germinal epithelium was observed after 1, 2, 3, 5 and 7 days of cadmium administration. A significant increase in the concentration of testicular cholesterol was observed after 5 days treatment. Decrease in the citric acid concentration of prostate gland was associated with the degenerative changes of the spermatogenic elements. Reduced fructose concentration in the seminal vesicle and prostate of cadmium treated animals indicate an inhibition of androgen production. Decreased androgen production was also reflected by the atrophic seminal vesicles, prostate and epididymides. These effects were reversible and about 70% seminiferous tubules showed normal spermatogenesis. The cholesterol, fructose and citric acid concentration of testis and sex accessory glands returned to subnormal levels after 45 days of cadmium chloride treatment. It is suggested that the degenerative effects of cadmium chloride are dose, time and species dependent.
单次皮下注射氯化镉会导致笔尾树鼩睾丸出现可逆性损伤。在给予氯化镉1、2、3、5和7天后，观察到睾丸重量和生精小管直径显著减小，同时生精上皮出现完全坏死。处理5天后，睾丸胆固醇浓度显著升高。前列腺柠檬酸浓度降低与生精细胞的退行性变化有关。镉处理动物的精囊和前列腺中果糖浓度降低，表明雄激素生成受到抑制。萎缩的精囊、前列腺和附睾也反映出雄激素生成减少。这些影响是可逆的，约70%的生精小管显示正常的精子发生。氯化镉处理45天后，睾丸和性腺附属腺的胆固醇、果糖和柠檬酸浓度恢复到低于正常水平。研究表明氯化镉的退行性影响取决于剂量、时间和物种。
