Sansone M, Battaglia M, Pavone F
Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.
Pharmacol Biochem Behav. 1999 Apr;62(4):613-8. doi: 10.1016/s0091-3057(98)00202-0.
The effects of the dihydropyridine calcium channel blocker nimodipine on avoidance impairment induced by the tricyclic antidepressant amitriptyline were assessed during shuttle-box training and in previously trained mice of the DBA/2 strain. Nimodipine (0, 0.5, 1, 2.5, or 5 mg/kg) had no effect alone, but attenuated the avoidance impairment induced by 5 mg/kg amitriptyline on avoidance acquisition, as well as on a previously learned avoidance response. The avoidance improving action of the calcium channel blocker was less evident in mice receiving a larger dose (7.5 mg/kg) of the antidepressant drug. The effect of nimodipine did not appear to be specifically related to the avoidance impairment induced by amitriptyline, because the calcium antagonist also attenuated the avoidance impairing action of the neuroleptic chlorpromazine. The avoidance impairment induced by amitriptyline and chlorpromazine, and the related ameliorating action of nimodipine, seem imputable to drug effects on the performance of the avoidance response, rather than to interferences with learning processes. The results suggest that, in the case of concomitant administration, nimodipine could alleviate adverse side effects of tricyclic antidepressant, i.e., psychomotor disturbances.
在穿梭箱训练期间以及对DBA/2品系的先前训练小鼠中，评估了二氢吡啶类钙通道阻滞剂尼莫地平对三环类抗抑郁药阿米替林诱导的回避障碍的影响。尼莫地平（0、0.5、1、2.5或5mg/kg）单独使用时无作用，但可减轻5mg/kg阿米替林对回避获得以及对先前习得的回避反应所诱导的回避障碍。钙通道阻滞剂的回避改善作用在接受较大剂量（7.5mg/kg）抗抑郁药的小鼠中不太明显。尼莫地平的作用似乎并非与阿米替林诱导的回避障碍特别相关，因为该钙拮抗剂也减轻了抗精神病药物氯丙嗪的回避损害作用。阿米替林和氯丙嗪诱导的回避障碍以及尼莫地平相关的改善作用，似乎归因于药物对回避反应表现的影响，而非对学习过程的干扰。结果表明，在联合给药的情况下，尼莫地平可减轻三环类抗抑郁药的不良副作用，即精神运动障碍。
