Kopp B, Kunkel A, Mühlnickel W, Villringer K, Taub E, Flor H
Department of Psychology, Humboldt University, Clinical Psychology and Behavioral Neuroscience, Berlin, Germany.
Neuroreport. 1999 Mar 17;10(4):807-10. doi: 10.1097/00001756-199903170-00026.
Neuroplasticity might play a beneficial role in the recovery of function after stroke but empirical evidence for this is lacking thus far. Constraint-induced (CI) therapy was used to increase the use of a paretic upper extremity in four hemiparetic stroke patients. Dipole modeling of steady-state movement-related cortical potentials was applied before and after training and 3 months later. The source locations associated with affected hand movement were unusual at follow-up because activation of the ipsilateral hemisphere was found in the absence of mirror movements of the unaffected hand. This long-term change may be considered as an initial demonstration of large-scale neuroplasticity associated with increased use of the paretic limb after application of CI therapy.
神经可塑性可能在中风后功能恢复中发挥有益作用，但目前尚无相关实证依据。对四名偏瘫中风患者采用了强制性诱导（CI）疗法，以增加患侧上肢的使用。在训练前后及3个月后，应用了与稳态运动相关皮质电位的偶极子模型。随访时，与患手运动相关的源位置异常，因为在未受影响手无镜像运动的情况下，发现同侧半球被激活。这种长期变化可被视为CI疗法应用后，与患侧肢体使用增加相关的大规模神经可塑性的初步证明。
