Chambers C A, Allison J P
Howard Hughes Medical Research Institute, Cancer Research Laboratory, Department of Molecular and Cellular Biology, 415 Life Science Addition, University of California, Berkeley, CA 94720, USA.
Curr Opin Cell Biol. 1999 Apr;11(2):203-10. doi: 10.1016/s0955-0674(99)80027-1.
During the past several years, the critical role of costimulatory molecules in regulating T cell responses has been demonstrated. Costimulatory molecule CD28 enhances whereas CTLA-4 downmodulates T cell responses. An understanding of the integration of the signals mediated by costimulatory molecules and the T cell receptor at the cellular and molecular levels is just beginning to be achieved.
在过去几年中，共刺激分子在调节T细胞反应中的关键作用已得到证实。共刺激分子CD28增强T细胞反应，而CTLA-4则下调T细胞反应。在细胞和分子水平上对共刺激分子和T细胞受体介导的信号整合的理解才刚刚开始。
