Kim J H, Huganir R L
Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Curr Opin Cell Biol. 1999 Apr;11(2):248-54. doi: 10.1016/s0955-0674(99)80033-7.
The organization and regulation of synaptic connections in the mammalian nervous system entail complicated and co-ordinated molecular and cellular processes. The unveiling of various protein-protein interactions and their functional consequences at synapses have led to a greater understanding of the process of synapse formation and the modulation of synaptic transmission. Recent studies indicate that the major excitatory neurotransmitter receptors in the brain, the glutamate receptors, are associated with many different molecules that are involved in the formation of elaborate synaptic cytoskeletal networks and signal transduction cascades. These complex protein networks may play critical roles in the regulation of neurotransmitter receptor function and the efficacy of synaptic transmission.
哺乳动物神经系统中突触连接的组织和调节需要复杂且协调的分子和细胞过程。各种蛋白质-蛋白质相互作用及其在突触处的功能后果的揭示，使人们对突触形成过程和突触传递的调节有了更深入的了解。最近的研究表明，大脑中的主要兴奋性神经递质受体——谷氨酸受体，与许多不同的分子相关联，这些分子参与了精细的突触细胞骨架网络和信号转导级联反应的形成。这些复杂的蛋白质网络可能在神经递质受体功能的调节和突触传递的效能中发挥关键作用。
