维生素E缺乏继发的脊髓小脑共济失调和多发性神经病
[Spinocerebellar ataxia and polyneuropathy secondary to vitamin E deficiency].
作者信息
Guiraud-Chaumeil C, Battaglia F, Tranchant C, Warter J M
机构信息
Service des Maladies du Système Nerveux et du Muscle, Hôpitaux Universitaires, Strasbourg.
出版信息
Presse Med. 1999 Mar 13;28(10):524-6.
BACKGROUND
Cerebellar ataxia or peripheral neuropathy can be signs of vitamin E deficiency. We report two cases.
CASE REPORTS
Two patients developed vitamin E deficiency subsequent to intestinal malabsorption. The first patient had a duodenogastric communication and dilatation of the first jejunal loop. The second patient had deficient pancreas secretion and dilatation of the biliary tree.
DISCUSSION
Vitamin E deficiency is generally secondary to acquired or hereditary malabsorption syndrome. It can also occur in the absence of malabsorption by hereditary deficiency in alpha-tocopherol transporter. Vitamin E supplements are required for malabsorption. The etiology work-up of neuropathy or cerebellar ataxia should include vitamin E assay.
背景
小脑共济失调或周围神经病变可能是维生素E缺乏的体征。我们报告两例病例。
病例报告
两名患者因肠道吸收不良继发维生素E缺乏。首例患者存在十二指肠与胃相通及第一段空肠袢扩张。第二例患者胰腺分泌不足及胆管扩张。
讨论
维生素E缺乏通常继发于获得性或遗传性吸收不良综合征。它也可在无吸收不良的情况下因α-生育酚转运蛋白遗传性缺乏而发生。对于吸收不良患者需要补充维生素E。对神经病变或小脑共济失调进行病因检查时应包括维生素E测定。
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