Calò P G, Porcu C, Pollino V, Cabula C, Malloci A
Istituto di Chirurgia e Oncologia Clinica, Università degli Studi, Cagliari.
Minerva Chir. 1998 Dec;53(12):1043-6.
Granular cell tumor of the male breast is an extremely rare neoplasm. The case of a 64-year-old man with a periareolar lump in the upper medial quadrant of his left breast of recent onset is reported. At clinical examination, it was a poorly circumscribed, irregular, hard, mobile 1 cm mass. No axillary lymph nodes were palpable. The patient was submitted to ultrasound scan which showed a 1 cm periareolar solid hypoechoic lesion with an acoustic shadowing and subsequently to fine needle biopsy that revealed the presence of also atypical ductal hyperplasia. For this reason he was submitted to excision biopsy. The definitive histology was of granular cell tumor. The immunohistochemical investigations showed an intense positiveness for S-100 protein; the staining with PAS showed a diffuse positiveness. At 18 months after treatment the patient had no recurrence of disease. Granular cell tumor of the male breast is a neoplasm whose differential diagnosis with carcinoma is often possible only with definitive histology. For this reason, also in front of a mammary lump strongly suspicious for carcinoma, it's always necessary to think it can be this neoplasm and therefore to wait for the necessary histopathologic confirmation.
男性乳腺颗粒细胞瘤是一种极其罕见的肿瘤。本文报道了一例64岁男性患者，其左乳上内侧象限乳晕周围出现近期发生的肿块。临床检查时，发现是一个边界不清、不规则、质地硬、可活动的1厘米肿块。未触及腋窝淋巴结。患者接受了超声检查，显示乳晕周围有一个1厘米的实性低回声病变，并伴有声影，随后进行了细针穿刺活检，结果显示还存在非典型导管增生。因此，他接受了切除活检。最终组织学检查确诊为颗粒细胞瘤。免疫组化研究显示S-100蛋白呈强阳性；PAS染色呈弥漫阳性。治疗后18个月，患者无疾病复发。男性乳腺颗粒细胞瘤是一种肿瘤，其与癌的鉴别诊断通常只有通过最终的组织学检查才能确定。因此，即使面对高度怀疑为癌的乳腺肿块，也始终有必要考虑可能是这种肿瘤，从而等待必要的组织病理学确诊。
