Souêtre E, Thwaites R M, Yeardley H L
Pharmacoeconomic Research, Glaxo Wellcome Research & Development, Middlesex, UK.
Br J Psychiatry. 1999 Jan;174:51-5. doi: 10.1192/bjp.174.1.51.
While the costs associated with Alzheimer's disease have been shown to be significant, there are few data relating cost of care to severity of the disease.
We aimed to compare the costs associated with different severities of Alzheimer's disease with those incurred by control subjects over a three-month period.
In this cross-sectional, multicentre, naturalistic analysis, non-institutionalised patients with Alzheimer's disease (128), their care-givers (128), and 56 matched controls were interviewed once to establish resource use over the previous three months. Patients were stratified into three severity groups according to their Mini Mental State Examination score. Costs were calculated from the perspective of society as a whole.
Over the three-month period, total mean cost per control subject (387 Pounds) was minor compared with mean cost incurred by patients with mild (6616 Pounds), moderate (10,250 Pounds) and severe (13,593 Pounds) Alzheimer's disease. Indirect cost, mainly time spent by care-givers, was the main cost component in all groups (68.6%), followed by direct medical costs (24.7%).
The cost of care for an Alzheimer's disease patient is directly related to the severity of the patients illness.
虽然已证明与阿尔茨海默病相关的费用很高，但很少有数据将护理成本与疾病严重程度联系起来。
我们旨在比较阿尔茨海默病不同严重程度患者与对照组在三个月期间产生的费用。
在这项横断面、多中心、自然主义分析中，对非机构化的阿尔茨海默病患者（128例）、他们的护理人员（128例）以及56名匹配的对照组进行了一次访谈，以确定前三个月的资源使用情况。根据简易精神状态检查表得分将患者分为三个严重程度组。从整个社会的角度计算费用。
在三个月期间，每个对照组的平均总费用（387英镑）与轻度（6616英镑）、中度（10250英镑）和重度（13593英镑）阿尔茨海默病患者产生的平均费用相比微不足道。间接成本，主要是护理人员花费的时间，是所有组中的主要成本组成部分（68.6%），其次是直接医疗成本（24.7%）。
阿尔茨海默病患者的护理成本与患者疾病的严重程度直接相关。
