Pietrantonio C
Ateneo Parmense Acta Biomed. 1976 Sep-Oct;47(5):613-33.
In this article the authors reconsider the literature about the drug treatment of sexual behaviour anomalies. In fact, the therapy of subjects convicted for sexual offences has been widely studied. The various drugs at disposal may be divided into three main groups: 1) oestrogens; 2) progesterone derivatives; 3) psycho-tropic-drugs. Among oestrogens the most widely used are oral stiboestrol and oestron. Recently, oestradio has been implanted subcutaneously. Even if effective all of them present some inconvenients, sometimes serious one, such as breast cancer. Recently drugs of the second group have been used. The most important of them is Cyproterone acetate, a synthetic substance, which is classified as antiandrogen and whose structure is like to progesterone. The effects in achieving a complete loss of libido and of sexual power have been judged satisfactory by all the authors who have experienced this drug. In U.S.A., where use of Cyproterone is still interdected, Medroxyprogersterone acetate is used parenterally and by depot with similar therapeutical effects. To the last group belong various drugs. The most used in benperidol, a neuroleptic, classified by many authors as antiandrogen.
在本文中，作者重新审视了有关性行为异常药物治疗的文献。事实上，对因性犯罪而被定罪者的治疗已得到广泛研究。现有的各种药物可分为三大类：1）雌激素；2）孕酮衍生物；3）精神药物。在雌激素中，最常用的是口服己烯雌酚和雌酮。最近，雌二醇已被皮下植入。即使所有这些药物都有效，但它们都存在一些不便之处，有时甚至是严重的不便，如乳腺癌。最近已使用了第二类药物。其中最重要的是醋酸环丙孕酮，一种合成物质，被归类为抗雄激素，其结构类似于孕酮。所有使用过这种药物的作者都认为它在完全丧失性欲和性能力方面的效果令人满意。在美国，由于仍禁止使用环丙孕酮，醋酸甲羟孕酮通过肠胃外和长效注射使用，具有类似的治疗效果。最后一类包括各种药物。最常用的是氟哌啶醇，一种抗精神病药物，许多作者将其归类为抗雄激素。
