Patti M E, Kahn C R
Research Division, Joslin Diabetes Center, Boston, MA 02215, USA.
J Basic Clin Physiol Pharmacol. 1998;9(2-4):89-109. doi: 10.1515/jbcpp.1998.9.2-4.89.
We have achieved significant progress in understanding the central role of the insulin receptor in an increasingly complicated web of intracellular signal transduction leading to the ultimate biological actions of insulin on glucose, lipid, and other metabolic pathways. The excitement for the future lies not only in clarifying these pathways but also returning to whole-body physiology to readdress basic mechanisms of insulin action in known and novel insulin-sensitive tissues. Hopefully, these new techniques and new perspectives will bring us closer to understanding the pathophysiology of type 2 diabetes mellitus.
在理解胰岛素受体在日益复杂的细胞内信号转导网络中的核心作用方面，我们已经取得了重大进展，该网络导致胰岛素对葡萄糖、脂质及其他代谢途径产生最终的生物学作用。未来令人兴奋之处不仅在于阐明这些途径，还在于回归整体生理学，重新探讨胰岛素在已知和新型胰岛素敏感组织中的作用基本机制。有望这些新技术和新观点将使我们更接近理解2型糖尿病的病理生理学。
