Nosten F, van Vugt M, White N J
Faculty of Tropical Medicine, Madihol University, Bangkok, Thailand.
Med Trop (Mars). 1998;58(3 Suppl):63-4.
The artemisinin derivatives are the most potent antimalarials. They are rapidly absorbed orally, parenterally and intra-rectally. The latter mode of administration is particularly interesting in rural tropics. Preliminary studies have shown that artemisinin and its derivatives artesunate and artemether are effective when given intrarectally. More studies are needed to establish the optimum regimen.
青蒿素衍生物是最有效的抗疟药物。它们通过口服、肠胃外和直肠内给药均可迅速吸收。后一种给药方式在热带农村地区尤其值得关注。初步研究表明，青蒿素及其衍生物青蒿琥酯和蒿甲醚经直肠内给药时是有效的。需要开展更多研究来确定最佳用药方案。
