Kelly K M, Littlefield T R, Pomatto J K, Ripley C E, Beals S P, Joganic E F
Cranial Technologies Inc., Phoenix, Arizona 85006, USA.
Cleft Palate Craniofac J. 1999 Mar;36(2):127-30. doi: 10.1597/1545-1569_1999_036_0127_ioerat_2.3.co_2.
Infants with positional plagiocephaly often exhibit complex multistructural asymmetries that affect the face and skull base as well as the cranial vault. Dynamic Orthotic Cranioplasty (DOC) was developed as a nonsurgical alternative for the treatment of positional plagiocephaly. The effectiveness of DOC has been discussed elsewhere. The purpose of this study was to assess the influence of factors such as entrance age, treatment time, and initial severity on the effectiveness of correction.
The study sample consisted of 258 children with cranial vault asymmetry (CVA) treated prior to 1 year of age. In addition, 246 patients (92%) exhibited concurrent skull base (SBA) and orbitotragial depth (OTDA) asymmetries. All patients had been diagnosed with nonsynostotic plagiocephaly, did not have other contributing medical conditions, were compliant with DOC protocol, and had complete anthropometric measurements at entrance and exit from treatment.
Mean age at start of treatment was 6.5 (+/-1.9) months (range, 2.8 to 11.0 months), with an average treatment time of 4.1 (+/-2.2) months. The effects of the treatment variables were analyzed using three-way analysis of variance. As expected, initial severity was significantly associated with the amount of correction (p = .0001). However, treatment time was not significant (p > .05). Most importantly, the analysis revealed that, having accounted for initial severity, entrance age had a statistically significant effect [F(1,254) = 8.36, p = .0042] on the correction of CVA. Similar results were identified for both the SBA [F(1,254) = 5.53, p = .0195] and the OTDA [F(1,254) = 5.22, p = .0231] asymmetries.
These findings support clinical observations that earlier intervention results in significantly improved treatment of plagiocephaly, independent of the severity of the presenting asymmetries.
患有体位性斜头畸形的婴儿常常表现出复杂的多结构不对称,这种不对称会影响面部、颅底以及颅顶。动态矫形颅骨成形术(DOC)是作为一种治疗体位性斜头畸形的非手术替代方法而开发的。DOC的有效性已在其他地方进行过讨论。本研究的目的是评估诸如开始治疗年龄、治疗时间和初始严重程度等因素对矫正效果的影响。
研究样本包括258名1岁前接受治疗的患有颅顶不对称(CVA)的儿童。此外,246名患者(92%)同时存在颅底(SBA)和眶耳深度(OTDA)不对称。所有患者均被诊断为非骨性融合性斜头畸形,没有其他相关疾病,遵循DOC方案,并且在治疗开始和结束时进行了完整的人体测量。
开始治疗的平均年龄为6.5(±1.9)个月(范围为2.8至11.0个月),平均治疗时间为4.1(±2.2)个月。使用三因素方差分析来分析治疗变量的影响。正如预期的那样,初始严重程度与矫正量显著相关(p = 0.0001)。然而,治疗时间并不显著(p > 0.05)。最重要的是,分析表明,在考虑初始严重程度后,开始治疗年龄对CVA的矫正具有统计学上的显著影响[F(1,254) = 8.36,p = 0.0042]。对于SBA[F(1,254) = 5.53,p = 0.0195]和OTDA[F(1,254) = 5.22,p = 0.0231]不对称也发现了类似结果。
这些发现支持了临床观察结果,即早期干预可显著改善斜头畸形的治疗效果,而与所呈现不对称的严重程度无关。