Yew D T, Chan W Y, Luo C B, Zheng D R, Yu M C
Department of Anatomy, Chinese University of Hong Kong, Hong Kong.
Biol Signals Recept. 1999 May-Jun;8(3):149-59. doi: 10.1159/000014586.
This is a review on the ontogenesis of major neurotransmitters and neuropeptides in the developing human central nervous system. In general, the molecules under study appeared early in development, usually in the first trimester. Cholinergic neurons were found to be present around the time of neuropeptide formation. The newly formed neuropeptidergic fibers extended towards the cholinergic centers where both might interact. In the major centers of the central nervous system, neuropeptides were also noted to colocalize with various neurotransmitters. For example, in the facial nucleus, enkepahlin and substance P fibers coexisted with cholinergic and catecholaminergic neurons, suggesting complex interactions. In the interpeduncular nucleus, peptidergic neurons acting as interneurons clearly modulated the afferent input to this nucleus. In the hippocampus and in sensory organs such as the retina, there were indications that neuropeptides and gamma-amino butyric acid coexisted. We hypothesize that interactions of neurotransmitters and peptides in neurons and fibers early in development play an indispensable role in the morphogenesis of the human central nervous system.
这是一篇关于发育中的人类中枢神经系统中主要神经递质和神经肽的个体发生的综述。一般来说，所研究的分子在发育早期出现，通常在妊娠早期。发现胆碱能神经元在神经肽形成时就已存在。新形成的神经肽能纤维向胆碱能中心延伸，二者可能在那里相互作用。在中枢神经系统的主要中枢中，还注意到神经肽与各种神经递质共定位。例如，在面神经核中，脑啡肽和P物质纤维与胆碱能和儿茶酚胺能神经元共存，提示存在复杂的相互作用。在脚间核中，作为中间神经元的肽能神经元明显调节该核的传入输入。在海马体和视网膜等感觉器官中，有迹象表明神经肽和γ-氨基丁酸共存。我们推测，发育早期神经元和纤维中神经递质与肽的相互作用在人类中枢神经系统的形态发生中起不可或缺的作用。
