Eis-Hübinger A M, Dieck D, Schild R, Hansmann M, Schneweis K E
Institute of Medical Microbiology and Immunology, Center of Obstetrics and Gynecology, University of Bonn, Germany.
Intervirology. 1998;41(4-5):178-84. doi: 10.1159/000024933.
Transplacental transmission of human parvovirus B19 (B19 virus) to the fetus is an important cause of intrauterine death, abortion, stillbirth, and nonimmune hydrops fetalis. Adverse outcome of pregnancy can occur after symptomatic and asymptomatic maternal infection. Only rare cases of congenital malformations and fetal disease in live-born infants have been associated with intrauterine B19 virus infection. Laboratory results obtained from paired maternal and fetal cord blood samples indicate that a reliable diagnosis of fetal B19 virus infection should be based on detection of parvovirus B19 DNA.
人细小病毒B19（B19病毒）经胎盘传播给胎儿是宫内死亡、流产、死产和非免疫性胎儿水肿的重要原因。有症状和无症状的母体感染后均可发生不良妊娠结局。仅有罕见的先天性畸形和活产婴儿胎儿疾病病例与宫内B19病毒感染有关。从配对的母体和胎儿脐带血样本获得的实验室结果表明，胎儿B19病毒感染的可靠诊断应基于检测细小病毒B19 DNA。
