Berger R, Busson-Le Coniat M
Unité INSERM U 434, Institut de Génétique Moléculaire, Paris, France.
Ann Genet. 1999;42(1):5-10.
Two patients with acute myeloid leukemia (AML-M7 and AML-M4) and trisomy 10 as the sole chromosome abnormality are reported. In the first patient, all karyotypes were abnormal. A karyotypically normal cell population was present in the second patient and the trisomic cells were less numerous than the normal ones at diagnosis. A review of the literature shows the rarity of isolated trisomy 10 in hematopoietic disorders and the diversity of the involved diseases. Moreover, in some patients, the trisomic cell population was less numerous than the normal one. These data are discussed in relation with the hypothesis that cells with trisomy 10 can belong to nonmalignant clones, at least in some cases, as previously shown for trisomy 7 in other conditions.
报道了两名急性髓系白血病患者（AML-M7和AML-M4），其唯一的染色体异常为10号染色体三体。在首例患者中，所有核型均异常。第二例患者存在核型正常的细胞群，且在诊断时三体细胞数量少于正常细胞。文献回顾显示，造血系统疾病中孤立性10号染色体三体罕见，且所涉疾病具有多样性。此外，在一些患者中，三体细胞群数量少于正常细胞群。结合以下假说对这些数据进行了讨论：至少在某些情况下，10号染色体三体的细胞可能属于非恶性克隆，正如之前在其他情况下7号染色体三体所显示的那样。
