Koffi A A, Darriet F, N'Guessan R, Doannio J M, Carnevale P
Institut Pierre Richet (OCCGE), Bouaké, Côte d'Ivoire.
Bull Soc Pathol Exot. 1999 Feb;92(1):62-6.
Susceptibility tests were carried out in laboratory conditions to evaluate the efficacy of alpha-cypermethrin (a synthetic pyrethroid never used in Côte d'Ivoire) for malaria vector control. Five wild populations of Anopheles gambiae originating from M'bé, Yaokoffikro, Korhogo, Kafiné and Daola and two laboratory reared strains (Kisumu susceptible and Kou permethrin resistant selected strain) were tested. The diagnostic dosage of alpha-cypermethrin for the sensitive strain Kisumu was 2.5 x 10(-3)%. A comparative study of the susceptibility of samples of wild populations of An. gambiae was carried out according to the WHO standard susceptibility test. Impregnated papers with 4% DDT, 0.25% permethrin, 0.025% deltamethrin and 0.0025% alpha-cypermethrin were used. The results showed that except for mosquitoes from M'bé, all the other populations were resistant to these insecticides. Bioassays were carried out with alpha-cypermethrin at the operational dosage of 20 mg a.i./m2 on the same population and laboratory reared strains. The results showed the efficacy of this insecticide on both the Kisumu strain and the population from M'bé, a maintained efficacy for the Daloa, Kafiné and Korhogo mosquito populations, but the wild anopheline population from Yaokoffikro clearly appeared fully resistant.
在实验室条件下进行了敏感性测试，以评估α-氯氰菊酯（一种从未在科特迪瓦使用过的合成拟除虫菊酯）对疟疾媒介控制的效果。测试了源自姆贝、姚科夫克罗、科霍戈、卡菲内和道拉的五个冈比亚按蚊野生种群以及两个实验室饲养品系（基苏木敏感品系和库氯菊酯抗性选择品系）。对敏感品系基苏木而言，α-氯氰菊酯的诊断剂量为2.5×10（-3）%。根据世卫组织标准敏感性测试，对冈比亚按蚊野生种群样本的敏感性进行了比较研究。使用了含4%滴滴涕、0.25%氯菊酯、0.025%溴氰菊酯和0.0025%α-氯氰菊酯的浸渍纸。结果表明，除了来自姆贝的蚊子外，所有其他种群对这些杀虫剂均具有抗性。在相同种群和实验室饲养品系上，以20毫克有效成分/平方米的操作剂量用α-氯氰菊酯进行了生物测定。结果表明，这种杀虫剂对基苏木品系和来自姆贝的种群均有效，对达洛阿、卡菲内和科霍戈的蚊子种群仍有效果，但来自姚科夫克罗的野生按蚊种群显然表现出完全抗性。
