Dummer T J, Pearce M S, Dickinson H O, Charlton M E, Salotti J, Parker L
North of England Children's Cancer Research Unit, Department of Child Health, University of Newcastle upon Tyne, UK.
Paediatr Perinat Epidemiol. 1999 Apr;13(2):131-7. doi: 10.1046/j.1365-3016.1999.00169.x.
The nuclear installation at Sellafield, in west Cumbria in the north of England, has discharged radioactive waste into the Irish Sea since 1952. The objective of this paper was to investigate whether women living near to the coast in Cumbria had an increased risk of having stillborn children. A retrospective cohort analysis was carried out using all 259,050 births (4017 stillbirths) to women normally resident in Cumbria during 1950-89, allowing for year of birth, social class and birth order using (i) comparison of observed and expected numbers of stillbirths in distance bands relative to the coast, (ii) comparison of cumulative observed and expected numbers of stillbirths by distance from the coast, and (iii) logistic regression analysis of stillbirth risk in relation to distance from the coast. Comparison of observed and expected numbers of stillbirths in distance bands within 10 km of the coast did not provide evidence of an excess risk of stillbirth closer to the coast. The comparison of the cumulative observed and expected numbers of stillbirths within 10 km of the coast supported this result. Logistic regression analysis of all births in Cumbria showed that distance from the coast did not significantly influence stillbirth risk (P > 0.05). There was no evidence to suggest an increased risk of stillbirth in mothers resident nearer to the coast.
位于英格兰北部坎布里亚郡西部的塞拉菲尔德核设施自1952年以来一直向爱尔兰海排放放射性废物。本文的目的是调查居住在坎布里亚郡海岸附近的妇女死产风险是否增加。采用回顾性队列分析,研究对象为1950 - 1989年期间常住坎布里亚郡的妇女所生育的全部259,050例婴儿(其中4017例死产),并考虑出生年份、社会阶层和出生顺序,方法如下:(i) 比较沿海岸不同距离区间内观察到的和预期的死产数量;(ii) 比较按与海岸距离划分的累计观察到的和预期的死产数量;(iii) 对死产风险与到海岸距离的关系进行逻辑回归分析。对海岸10公里范围内不同距离区间内观察到的和预期的死产数量进行比较,未发现靠近海岸处死产风险过高的证据。对海岸10公里范围内累计观察到的和预期的死产数量进行比较,支持了这一结果。对坎布里亚郡所有出生情况进行逻辑回归分析表明,与海岸的距离并未显著影响死产风险(P > 0.05)。没有证据表明居住在靠近海岸的母亲死产风险增加。